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3M has commissioned the UCD based National Institute for Bioprocessing Research and Training (NIBRT) to carry out in-depth research into its Emphaze AEX Hybrid Purifier. 3M believes Emphaze could have a significant impact on the biotechnology industry.

The project will be a collaborative one comprising two studies each carried out independently by NIBRT with results expected in early 2018.

The first study is already underway and began in January 2017 with a completion date in the third quarter of this year. It is examining the effect of chromatographic clarification on host cell DNA and the specific type and quantity of host cell proteins removed prior to downstream processing. The second phase of the research work will build on the results of the first study and will investigate the performance gains from optimising the load conditions for the Emphaze device.

The Emphaze AEX Hybrid Purifier is part of the 3M Emphaze suite and combines chromatographic functionality with a filter matrix in a single use “plug and play” device. The structure allows the device to be deployed during the clarification process whilst significantly reducing soluble impurities.

The aim of the NIBRT research is to quantify and qualify the impact on the downstream process in terms of complexity and cost. Dr Jonathan Bones, principal investigator at NIBRT, believes the research will be vitally important for highlighting the value of Emphaze AEX Hybrid Purifier for the biotechnology industry.

“The data from this project will be highly impactful and will empower the industry to confidently implement the technology and increase efficiency in the purification process,” Dr Bones said. Dr Hani El-Sabbahy, biopharmaceutical engineering specialist at 3m said the research will yield some powerful results. “3M is dedicated to advancing technologies and improving efficiencies in the biopharmaceutical industry” he said.